Enzyme Inhibitor Screening

Specialized for lead discovery, BioAssay Systems has developed a range of assays for screening enzyme inhibitors. Our enzyme inhibitor screening services include, but are not limited to, determination of EC50 or IC50 and mode of action for lead compounds.

Clients are welcome to contact us via email at service@bioassaysys.com or via phone at 1-877-782-3888 x 2 about their specific needs.

Enzyme Inhibitor Screening
  • Determine Enzyme Km
  • Measure solvent interference
  • Determine Inhibitor IC50
  • Available Enzymes
Examples of Previous Enzyme Inhibitor Screening Services
  • Arginase Inhibitor Assays Arginase is a drug target for various diseases, such as cancer, hypertension, atherosclerosis, myocardial ischaemia, congestive heart failure, and diabetes mellitus.
    Assay details: html  ∣   pdf.

  • PTP1b Inhibitor Assay. Protein tyrosine phosphatase 1B (PTP1B) is a key regulator and primary drug target for type 2 diabetes and obesity. It is also involved in liver regeneration, drug-induced liver disease, non-alcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma.
    Assay details: html  ∣   pdf.

  • Monoamine Oxidase Inhibitor Assays. Monoamine oxidase is involved in removing the neurotransmitters norepinephrine, serotonin and dopamine from the brain. Monoamine oxidase inhibitors (MAOIs) were the first type of antidepressant developed.
    Assay details: html  ∣   pdf.

  • Acetylcholinesterase Inhibitor Assays. Acetylhydrolase is the primary cholinesterase that catalyzes the breakdown of acetylcholine and other choline esters that function as neurotransmitters. Acetylcholinesterase inhibitor is a drug that inhibits the breakdown of acetylcholine, thus increasing both the level and duration of action of the neurotransmitter acetylcholine.
    Assay details: html  ∣   pdf.

  • Aldehyde Dehydrogenase Inhibitor Assays. Aldehyde Dehydrogenases (ALDHs) are a family of enzymes crucial to alcohol metabolism, catalyzing the breakdown of acetaldehyde. Elevated levels of ALDHs have also been associated to certain cancer types. Cancer Stem Cells (CSCs) with heightened levels of ALDHs have shown enhanced survival mechanisms leading to resistance to chemotherapy and radiation.
    Assay details: html  ∣   pdf.

For inquiry to BioAssay Systems' Enzyme Inhibiotor Screening contact us via email at service@bioassaysys.com or via phone at 1-877-782-3888 x 2.

Customer Testimonials

Edward T. Wei, Chief Scientific Officer, Orinda Pharma, Inc.
"It is a pleasure working together with BioAssay Systems. I brought samples to their Hayward location and received the results in less than 24 hr. The discussion with Robert Z was courteous, open, and with a depth of knowledge. Robert has a PhD from Stanford. Also, Frank Huang, the CEO, had sufficient scientific curiosity to try out our cleanser and provide feedback! This is beyond the call of customer relations. BioAssay Systems is a company with a lot of expertise and a friendly, responsive approach to problem solving. I will enthusiastically continue to work with them to carry out our research."

Anh-Dung Le, CEO DermaTec LLC
"The guys at BioAssay Systems know their science! I had to develop a bioassay for our company and Robert was very quick to respond to keep us up to date. They are knowledgeable and very resourceful. They directed us to one of the bulk suppliers that could give us a really good deal on our active ingredient. They keep very detailed records for our research needs. I would recommend working with BioAssay Systems on your assay development projects!"